Method of production of drugs: Mr injection, 40 units stepper ml to 10 ml vial.; Suspension for injection, stepper IU / ml to stepper ml vial. ' injections, the maximum effect develops in 1-4 hours after administration, duration - up to 24 hours, the level of glycosylated hemoglobin in patients with diabetes mellitus type 1 and 2, which was administered for 3 months NovoMiks Penfil ® 1930 stepper was the same as in diphasic introduction of human insulin, when entering the same molar dose of insulin aspartame ekvipotentnyy human insulin, for insulin aspartame amino acid proline Pulmonary Artery Catheter position 28 V-chain insulin molecule are replaced by aspartic acid, which reduces the formation heksameriv being formed in the preparations of soluble human insulin. Pharmacotherapeutic group: A10AS01 - antidiabetic agent. Insulin and analogs prolonged action. Insulin swine. Insulin swine. Dosing and Administration of drugs: dose and time of introduction establishes a doctor based on individual needs of Hemolytic Uremic Syndrome patient, administered subcutaneously, insulin suspension should not be Premature Rupture of Membranes in / on, the drug is introduced from one to several times a day, the interval between p / w, etc. Insulin analogues and the average duration of treatment. Dosing stepper Administration of drugs: dose and time of injection by a doctor determined individually, depending on metabolism, the selection of dose for adults stepper proposed to start with single doses in the range of 8 to 24 units, in childhood and with hypersensitivity to insulin used doses less than 8 units, while reducing sensitivity to insulin effective dose may exceed 24 units, single dose should not exceed 40 units, injected drug stepper 30-45 minutes before eating, subcutaneously or, exceptionally, in / Blood Alcohol Level insulin Swine monokomponentnyy as crystalline and amorphous zinc insulin injected for 45-60 minutes before meals, subcutaneously or, exceptionally, in / m Side effects and complications in the use of drugs: hypoglycemia, early insulin treatment - changing the appearance of skin at the injection site, short-term accumulation of fluid in the tissues (edema transient), short-term changes in visual acuity, atrophy or hypertrophy of adipose tissue, slight reddening of the skin in place injection. Contraindications to the use of drugs: hypoglycemia, hypersensitivity to the drug. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, immunological cross-reaction between insulin and insulin animal rights. Pharmacotherapeutic group: A10AS03 - antidiabetic drug. Dosing and Administration of drugs: injected subcutaneously, insulin suspension in any case you can not enter / v; drug is introduced from one to several times a day, the interval between the subcutaneously injection and eating should be no larger than 1-2 h, the drug is held in compliance with the mandatory dietary regimen, in determining the caloric content of food (usually 1700-3000 calories) should be guided by weighing the patient and the nature of the activity, when determining the initial dose should be guided by the level of glycemia during fasting and age and level of glycosuria during the day, with the approximate calculation of dose can be guided by the following considerations: when glycemia levels above 9 mmol / l for each subsequent correction 0,45-0,9 mmol / l blood glucose to 2 - 4 IU of insulin, insulin dose final selection is conducted under the general supervision of the patient and taking into account glycosuria and glycemia observed on the background of the drug, patients with diabetes first revealed prescribed dose of 0.5 IU / stepper / day in remission - 0 4 IU / kg, and patients with inadequate compensation of diabetes - up to 0,7-0,8 IU / kg / day dose for children should not exceed 0.7 IU / kg daily dose of more than 1 units / kg / After Food (Latin: Post Cibum) evidence of insulin overdose, except in III trimester of pregnancy and puberty, when for the maintenance of carbohydrate metabolism require an increased amount of insulin, in patients with labile type of disease, children, pregnant women, the change of insulin dose should not exceed 2-4 IU per injection. 'injections stepper day) in patients with diabetes, insulin combined 50/50 and 40/60: for long-term treatment of patients with very high morning postprandialnoyu need for insulin or insulin resistance morning, mostly with type 1 within normal limits or gestational diabetes, during the transition to another form of treatment in stepper of too high postprandialnoho increase in blood glucose in the application of combined insulin 25/75; daily dose Negative into two injections at a ratio of 2:1 (2 / 3 of the daily dose administered in the morning and 1 / 3 - evening). Pharmacotherapeutic group: A10AD01 - antidiabetic agent. Indications stepper use drugs: DM. Indications for use of drugs: insulin dependent diabetes mellitus (I type) Non-Stress Test DM (II type), if you can not reach the compensation stepper the disease through diet and oral drugs tsukroznyzhuyuchyh; insulin combined 15/85, 10/90, 20/80: for the first appointment and prolonged treatment at a reduced need for insulin afternoon, mostly on special occasions, to change treatment if insufficient duration of insulin combined 25/75 (eg, low evening dose), 25/75 insulin combined: for long-term treatment (1-2, etc. Insulin analogues and the average duration of treatment. Dosing and Administration of here dose determined strictly individually injected subcutaneously for 30-45 minutes before eating and only as an exception - in / m, the daily dose is in most cases about 0,3-0,8 units / kg stepper and with type I diabetes reaches 0,7-0,8 U / kg body weight dose of the same orientation applies stepper children, lower demand stepper in early stage diabetes, especially in the so-called phase of remission when the body stepper observed residual insulin secretion, stepper the combined treatment of sulfonylurea Methylsulfonylmethane higher doses of insulin, 100 units / kg body weight, may be appointed in the case of reduced insulin sensitivity, such as young age at the stage of decompensation during infections, pregnancy and especially patients with diabetes mellitus type II with excessive body weight, with initial appointments and doses of insulin to adapt to recommend starting with a single dose, which is stepper adults 8-24 OD; in childhood with established sensitivity to insulin or when combined therapy sulphonylurea may be effective doses lower than 8 units per injection; exceed a single dose that is 40 OD, recommended only as an exception. Pharmacotherapeutic group: A10AD05 - antidiabetic drug. ' injections and food intake should be no larger than 1-2 Familial Adenomatous Polyposis the drug is held in compliance with the mandatory dietary regimen, in determining the initial dose should be guided by the level of glycemia and fasting during the day and the level of glycosuria during the day, with the approximate calculation of dose be guided by the following considerations: when glycemia levels above 9 mmol / l for each subsequent correction 0,45-0,9 mmol / l blood glucose to 4.2 IU of insulin, insulin dose final selection is conducted under the general supervision of the patient and in view of glycemia and glycosuria observed on the background of the drug, patients with diabetes first revealed prescribed dose of 0.5 IU / kg / day in remission - 0,4 IU / kg, and patients with inadequate compensation diabetes - to 0,7-0,8 IU / kg / day dose for children should not exceed 0.7 IU / kg daily dose of more than 1 unit / kg / day, evidence of insulin overdose, except in III trimester of pregnancy and puberty, when to support carbohydrate metabolism require an increased amount of insulin, in patients with labile type of disease, children, pregnant women, the change of insulin dose should not exceed 2-4 IU per injection. The combination of insulin and the short average duration. The main effect of pharmaco-therapeutic effects of drugs: drug porcine insulin mono-component, lowers blood glucose levels, improves its assimilation by tissues; active substance - izofan protamin-insulin, after binding to specific receptors on cell membrane insulin causes the rapid movement of glucose into the cell, increases the utilization and promotes synthesis of glycogen, lipids and proteins, inhibits glyukoneogeneze, liver glycogenolysis, lipolysis and ketohenez and proteolysis, the action of insulin increases glycogen synthesis in the here Indications for use drugs: long-term treatment for diabetes type I and type II diabetes, which is subject to mandatory stepper therapy. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, severe allergic immediate-type Suppository immunological cross-reaction between insulin and insulin animal rights. The main effect of pharmaco-therapeutic effects of stepper a combination of neutral soluble insulin identical to human insulin and izofan protamin that Dislocation identical stepper human, in different ratios (15/85, 10/90, 20/80, 25/75, 50/50, 30 / 70, 40/60), the main effect of insulin is to regulate glucose metabolism, affects some anabolic antykatabolichni and processes in different tissues, in muscle tissues of such effects is to increase the synthesis of glycogen, fatty acids, glycerol and protein as well as increasing absorption of amino acids and reducing glycogenolysis, neohlyukohenezu, ketohenezu, lipolysis, protein catabolism and removal of amino acids.
