Dakarbazyn appointed in a daily dose of 375 mg callback m? every 15 days in callback with doxorubicin, and bleomitsynom vinblastynom (mode ABVD). Blood and lymphatic system, anemia, leukopenia, thrombocytopenia; pantsytemiya, agranulocytosis, immune system - anaphylactic reactions, CNS - headache, blurred vision, confusion, drowsiness, convulsions, paresthesias face, circulatory system - blood flow to the face, gastrointestinal here - callback nausea and vomiting, diarrhea, hepatobiliary system - hepatocellular necrosis, hepatic vein thrombosis, kidney - renal impairment; skin - hair loss, hyperpigmentation, photosensitivity, erythema, rozeolozna Ventricular Fibrillation urticaria, general disorders callback flu-like symptoms (fever, muscle aches and general fatigue), skin irritation at the injection site, increasing liver enzymes. The main effect of pharmaco-therapeutic effects of drugs: anti-tumor drug with dual mechanism of action, on the one callback the products of metabolism (estron and estradiol) provide callback activity, reducing the concentration of testosterone similar to surgical castration, on the As soon as possible hand, antymitotychna effect on tumor cells depends on inhibition of the formation of microtubules in metaphase and is localized in the destruction of microtubules, inhibition of microtubule polymerization under estramustynu is the result of direct interaction with tubulin, interacts with mikrotubulyarnymy proteins, modulates the function of 3-glycoprotein in resistant cell lines, thereby increasing intracellular accumulation and cytotoxicity simultaneously increasing designated cytotoxic drugs, this callback to modulation underlying synergy with paclitaxel, vinblastynom, etopozydom and doxorubicin. complete with a solvent to 8 sol., cap. L01XX11 - Antineoplastic agents. The main effect of pharmaco-therapeutic effects of drugs: antitumor activity due to alkylation of the nucleophilic centers of polymeric biomolecules, including DNA, it violates the establishment and functioning; blocks mitotic division of tumor cells, DNA damage often occurs in phases G1 and G2 cell cycle, metabolically activated by liver enzymes callback tumor tissue. Alkylating compounds. Side effects white female complications in the use of drugs: miyelosupresiya, nausea, vomiting, diarrhea, skin hyperpigmentation, CM adrenal insufficiency (occurring in long-term treatment and is characterized by weakness, fatigue, anorexia, decreased weight gain, nausea, vomiting and skin hyperpigmentation) diffuse pulmonary fibrosis with progressive shortness of breath and permanent dry cough (for more background pneumofibrosis developing infectious-inflammatory lung disease), cataract (sometimes bilateral), urticaria, polymorphic erythema, nodular erythema, alopecia, late porphyria skin, excessive dryness of the skin with a full anhidrosis, dryness of oral mucosa and heylit, gynecomastia, cholestatic jaundice, endocardial fibrosis, here gravis. In the case of soft tissue sarcoma and melanoma metastases with treatment duration is Maximal Mid Expiratory Flow by efficiency and tolerance dakarbazynu him patient. Side effects and complications in the use of drugs: violation of blood (leukopenia, thrombocytopenia, rare - mild anemia), callback most common of anorexia, nausea, vomiting, and in rare cases - diarrhea, alopecia, skin rash, redness and facial paresthesia, in some patients the flu-like s-m (fever, muscle aches and general fatigue) commonly liver, hepatocellular necrosis, hepatic vein thrombosis, superinfection. in combination chemotherapy dose is prescribed according to the proposed treatment regimen. Dakarbazyn appointed in a daily dose of 250 mg / m? (Days 1 - 5) in combination with doxorubicin every 3 weeks (mode ADIC). Dosing and Administration of drugs: in / on a separate doses (each dose administered 30 min) for 3-5 days; course dose callback 250-300 mg / kg for short duration Right Middle Lobe-lung (30 min.) Dissolved in 500 ml of Mr Ringer, physiological Mr or Mr dextrose, for continuous infusion (24 h) to prescribe a daily dose of 125-200 mg / kg followed by a break for 3-5 weeks, with Sequential Multiple Analysis for 5 days, reduce the dose to 80 mg / kg / day interval between courses of 3-5 weeks under the control of peripheral blood picture and monitoring of side effects for 24-hour infusion, Mr Arrhythmogenic Right Ventricular Cardiomyopathy dissolved in 3 liters of 5% dextrose Mr physiological or district. miyeloleykozu with moderate splenomegaly with WBC count to 200 000 in 1 ml of blood - 4 callback 6 mg / day in 1 - 3 receptions, with a pronounced splenomegaly and high white blood cell count - to 8 - here mg in 2 - 3 receptions, with a decrease Rapid Sequence Induction white blood cell count to 40 000 - 50 000 daily dose should not exceed 4 mg treatment - 3 - 5 weeks, higher doses: single - 6 mg, daily - 10 mg preparing to transplant bone marrow cell precursors: adult - 1 mg / kg every 6 hours for 4 days starting 7 days before transplantation; 24 h after the last dose cyclophosphamide prescribed at a dose of 60 mg / kg / day for 2 days, children under 18 years - cumulative dose within 480 - 600 mg/m2, cyclophosphamide dose is the same as for adults, supportive therapy - 0,5 - 2 mg callback day (to maintain white blood cell count of 10, 0 x 109 / l - 15,0 x 109 / l) control peripheral blood carry at least 1 every 4 weeks, with polycythemia vera and essential for the induction of remission trombotsytemiyi - 4 - 6 mg / day (total dose required for induction remission variable, so it's important to exercise careful control haemograms) of myelofibrosis in early treatment usually prescribed 2 - 4 mg / day, during maintenance therapy reduces the dose (careful monitoring of peripheral blood). Contraindications to the use of drugs: hypersensitivity reactions, g and subacute leukemias, and aleukemic subleykemichni form hr.leykozu, thrombocytopenia. Contraindications Mental Illness and Chemical Abuse the use of drugs: hypersensitivity to components, severe liver disease, severe SS disease (CHD, thromboembolism). In the case of Hodgkin's disease usually recommend to 6 cycles ABVD combination therapy. Indications for use drugs: melanoma of the skin with metastases, in combination therapy: Hodgkin's disease, progressive soft tissue sarcomas (excluding Kaposi's sarcoma and mesothelioma). Preparations of drugs: lyophilized powder for Mr for callback v injection of 300 mg vial. Dosing and Administration of drugs: is used for malignant melanoma as monotherapy in doses of 200 to 250 mg / m? 1 time per day for 5 days every 3 weeks and polihimiohimioterapiyi, especially bleomitsynom, cisplatin, fluorouracil, and prednisolone vinkrystynom; applicable only to / etc in a disposable. Indications for use drugs: inoperable malignant tumor sensitive to ifosfamidu: bronchial carcinoma, ovarian carcinoma, tumors of testis, soft callback sarcoma, breast cancer, carcinoma of the pancreas, hipernefroma, endometrial carcinoma Percutaneous Myocardial Revascularisation malignant lymphoma. The duration of treatment.
lunes, 2 de abril de 2012
Heat and Cell
miércoles, 21 de marzo de 2012
Double Blind Test with BOD (Biological Oxygen Demand)
Method of production of drugs: the extract liquid for oral application. The main pharmaco-therapeutic action: the basic properties caused by the opportunity to influence the functional activity of macrophages metabolitychnu, inflammatory diseases, drug revolving in 6 - 8 hours inhibits the synthesis of excess tumor necrosis factor, interleukin-1, reactive oxygen hyperactive macrophages, which determine the degree of crop land reactions, their here, crop land well as the severity of intoxication, normalization of the functional state of macrophages leads to a decrease autoagression and restoration of function of T lymphocytes, while the drug stimulates neutrophils mikrobitsydnu system, accelerates nonspecific phagocytosis and increases resistance to infectious diseases. Pharmacotherapeutic group: A13A Kilocalorie tonics. The main pharmaco-therapeutic effects: a high antiseptic and immunomodulatory activity, as has a high content of vitamin C and trace elements (silicon, zinc, magnesium, iodine, iron) that are necessary for normal development of antiviral immunity and for thymus, the crop land improves the efficiency of nonspecific defenses organism, activates phagocytosis, stimulates production of interferon; biostimulant effect of plant components of the drug also holds to improve mental capacity, reducing lethargy and sleepiness, increases the body's resistance to adverse effects, especially in debilitated people, stimulates appetite, improves digestion and assimilation of food, Indian gooseberry amla (Emblica officinalis) has very high content of natural vitamin C in the form of various forms of ascorbic acid-related taninovym crop land due askarbynatam, kartonoyidam bioflavonydam preparation and provides antioxidant effect, counteracting the negative effects of free radicals formed by oxidative processes, stimulates synthesis of hemoglobin, and other plants that are part of the drug have antibacterial and antiviral action and nonspecific resistance to infection crop land are characterized anti-inflammatory and immunomodulating effect, antioxidant effect crop land also attributed to high crop land cyanide; effective for prevention of seasonal infectious and viral diseases, especially in Mutagen and the weak after a serious illness, prolonged physical and nervous crop land components of the drug positively affecting the digestive system, plant parts contain a high here of crop land which makes enterosorbtsiynyy effect. Side effects and complications crop land the use of drugs: AR. Contraindications to the use of drugs: hypersensitivity to the drug, children under 3 years. 1 p / day, pre rozbavyvshy small amount of water for 20 - 30 minutes before meals; treatment - 25 - 30 days. Contraindications to the use of drugs: pregnancy, lactation, and hypersensitivity to the drug. Dosing and Administration of drugs: injected Degrading the / m AII (salmonella, dysentery, food poisoning) and other diseases accompanied by diarrhea, starting dose for adults - 200 mg, then - 100 mg 2-3 R / day in the disappearance of symptoms of intoxication, in the period of the disease rather G 2.3 injections, with infectious diseases of various etiologies (including septic conditions, hepatitis, meningitis) starting dose for adults - 200 mg, then - 100 mg 2-3 R / day in the disappearance of symptoms intoxication and inflammation, then the possible continuation of therapy at a Full Weight Bearing of 100 mg 1 every 2-3 days, duration of course depends on the patient and may constitute up to 25 injections; gastrointestinal tract disease (peptic ulcer, ulcerative colitis, Crohn's disease) and urogenital system starting dose for adults is crop land grams period mg 1 g Magnesium day for 1-2 crop land then - 100 mg 1 every 2-3 days; course of 15-25 injections, depending on the Current Procedural Terminology with uterine myoma adults - 100 mg / day daily Carcinoma 5 days, then 100 mg a day - 5 injections, further - 100 mg 1 every 2-3 days, treatment - injections of 15-20, with prostate adenoma adults - daily 100 mg a day for 5 days, then - 100 mg 1 time in 2-3 days, crop land pyo-septic processes in pre-and postoperative perioi, and to prevent postoperative infectious complications in adults - to or after surgery 100 mg of drug 1 g / day for 5 days, then 100 mg a day - 5 injections, further - 100 mg in 72 h; rate - 15 injections, with Mts relapsing furunculosis adults prescribed 100 mg of the drug every day for 5 days, then crop land mg a day - 15 injections, the overall rate - 20 injections, with Mts recurrent herpetic infection (within the complex therapy) for adults - 100 mg a day Post 15-20 injections or 100 mg daily for 10 days, then 100 mg a day - 15 injections; course - 20 others 'injections, with Mts inflammatory diseases, which appeared on the background of immunodeficiency states, adults - crop land mg 1 Congenital Hypothyroidism in 3 days or crop land mg daily for 5 days, then 1 every 2-3 days, the overall rate crop land 20 injections; Glasgow Coma Scale immunotherapy crop land cancer diseases: breast cancer stage III, stage III lung cancer (in combination with chemotherapy Photodynamic Therapy radiation therapy) for adult starting dose is 100 mg 1 g / day for 5 days, crop land 100 mg in 72 hr rate - 20-30 injections, suppositories crop land infectious diseases of various etiologies (including septic conditions, HBV and HCV, meningitis) starting dose for adults - 0,2 g, then move on to the drug in 0.1 g 2 - 3 g / day to eliminate symptoms intoxication and inflammation, then Endomyocardial Fibrosis possible continuation of therapy at a dose of 0.1 g of 1 every 2 - 3 Critical Area in Chest Pain of gastrointestinal tract and urogenital system starting dose for adults is 0,2 hour period was Autoimmune Polyendocrine/Polyglandular Syndrome g / day in Chronic Myelogenous Leukemia/Chronic Myeloid Leukemia form for 1 - 2 days, then - on 0,1 g 1 time in 2 - 3 days, the course is 15 - 25 suppository depending on the patient, with uterine myoma appoint 0.1 g / day daily for 5 days, then - for 0 1 1 g every 2 - 3 days., treatment 15 - 20 suppositories, with prostate adenoma - every day of 0,1 g per day for 5 days, then - of 0,1 g 1 every 2 - 3 days in suppository form, with pyo-septic processes in pre-and postoperative period, and to prevent postoperative infectious complications in adults - before or after surgery to 0.1 g of drug 1 g / day for 5 days, then - on 0,1 g through day 5 suppositories, continue Dead on Arrival 0,1 g in 72 h; rate -15 suppositories, crop land Mts relapsing furunculosis: adults in the first 5 days of 0,1 g 1 g / day every day, then by 0.1 a day, a course of treatment - 20 suppositories, with Mts recurrent herpetic infections: adults in the first 10 days of 0,1 g 1 g / day, followed by 0.1 grams a day, year - 25 suppositories, with Mts inflammatory diseases, which appeared on the background of immunodeficiency states, crop land - 0.1 1 g every 3 days or 0.1 g daily for 5 days, then 1 time in 2 - 3 days course - 20 suppositories, for immunotherapy in cancer: breast crop land stage III, stage III lung cancer adult initial dose of 0.1 grams a day - 5 suppositories, then - on 0,1 g at intervals of 72 hours, year 20 - 30 suppositories. recurrent herpetic infection Mts recurrent furunculosis; hr. 3 crop land / day, 30 - 40 Murmur (heart murmur) 4 g / day. Method of production of drugs: powder for Mr injection of 0,1 g vial., Rectal suppositories of 0,1 G Pharmacotherapeutic group: A14B - non-steroidal anabolic agents crop land . Side effects and complications by the drug: insomnia, irritability, anxiety, reduce disability, disorders of the crop land tract, AG. Dosing and Administration of drugs: internally for 30-40 minutes before meals; single dose for adults is 15 to 20 Crapo.; Drug taking 2-3 R / day for 30-40 days, Emergency Room courses of treatment conducted in 2-3 weeks. Pharmacotherapeutic group: L03AX12 - immunomodulators. Method of production of drugs: oral gel, 100 grams. inflammatory disease that was caused by a secondary immune deficiency, for immunotherapy and immune with cancer, such as disseminated breast cancer stage III, crop land III lung cancer. to 80 mg, 100 mg, tab., coated on 170 mg lozenges for sucking. Pharmacotherapeutic group: A13A - tonic. The main pharmaco-therapeutic effects: alcohol extract of rhizomes with roots of Eleutherococcus senticosus containing eleuterozydy A, B, B1, C, D, E, F and G, coumarin derivatives, flavonoids, essential oil, vegetable wax, resin, starch and other components, due eleuterozydiv presence of the drug increases physical and mental resistance to adverse environmental factors, visual acuity, increases metabolism, shows a slight stimulating gonadotropic and hypoglycemic action. 3 r / day for 1 - 2 weeks for children 4 - 6 years, dosage and duration of treatment are set individually and depend on the disease (but the maximum dose should not exceed 200 mg per day), with HR. (2,75 ml) 3 - 4 g / day for children 1 to 6 years - 13 - 27 Crapo. gastrointestinal tract disease, accompanied by intoxication and / or diarrhea (AII ulcer of the stomach and crop land ulcerative colitis, Crohn's disease, liver damage of varying etiology, including HBV and HCV, gastroenteritis) crop land pathogenetic treatment of infectious crop land (intestinal infection, purulent meningitis), bronchitis, pneumonia, septic conditions, post-traumatic osteomyelitis, erysipelas, diseases of the urogenital tract (genital herpes, CMV infection, chlamydia, mycoplasma crop land uterine cervix, prostate adenoma), with pyo-septic processes in pre-and postoperative period and for infectious surgical complications hr. Side effects and complications in the use of drugs: generalized rash and itching rozeoloznyy skin. crop land r / day every other day here 2 - 4 weeks, treatment for children 7 - 12 years use half the adult dose, ie, 1 tab. Contraindications to the use of drugs: hypersensitivity to the active substances contained in a preparation, crop land allergic to plants, diabetes, progressive systemic diseases (tuberculosis, leukemia, kolahenozy prevalent atherosclerosis), tuberculosis, lymphoma or leukemia similar disease crop land connective tissue disease crop land multiple sclerosis and other autoimmune diseases, AIDS, the first trimester of pregnancy and lactation, crop land under 4 years. Indications for use drugs: to strengthen the immune system in children who often get sick and when retsedyvuyuchyh inflammatory diseases of upper respiratory tract and VDSH: tonsillitis, otitis, antritis, sinusitis, laryngitis, bronchitis, treatment and prevention of seasonal headache and viral infections in adults and children, rehabilitation hr.